St Stephen's College of Nursing was established in 2008. The college was initially started as the St Stephen’s School of Nursing in 1888 which later got changed to College of Nursing in 2008. It also has a hospital named St Stephen’s Hospital, Delhi which was established in 1885 by St. Stephen’s Hospital Society which was initially started with only 50 beds. The hospital currently has 595 beds providing medical treatments in various specialities. St Stephen's College of Nursing, Delhi is affiliated to Guru Gobind Singh Indraprastha University (GGSIPU).

St Stephen's College of Nursing, Delhi is located in Tis Hazari, New Delhi. The nearest airport from the institute is the Indira Gandhi International Airport which is located 17.3 km away and students can reach the campus in approximately 28 mins. The nearest railway station from the institute is the New Delhi Railway Station which is 4.7 km away and students can reach the campus in about 13 mins. Old Delhi Railway Station is also located near the college which is about 2.8 km away and students can reach the campus in about 5-10 mins. The nearest metro station from St Stephen's College of Nursing is Tis Hazari Metro Station which is 1.2 km away and students can reach the campus in approximately 4 mins.